Projection patterns of surviving neurons in the dorsal lateral geniculate nucleus following discrete lesions of striate cortex: implications for residual vision

Abstract

In four monkeys with long-standing partial ablation of the striate cortex pellets of horseradish peroxidase were placed in either the striate cortex immediately adjacent to the ablation, or in the extrastriate cortex of the ventral prelunate gyrus, i.e. in visual area V4. We examined the dorsal lateral geniculate nucleus to see whether surviving neurons, within the region that shows retrograde degeneration as a result of the cortical lesion, project to remaining striate cortex and/or to extrastriate cortex. Neurons labelled from extrastriate cortex were found throughout the degenerated region, whereas neurons labelled from striate cortex were confined to the border between the normal and degenerated region of the nucleus. This shows that isolated neurons found within the degenerated region survive striate cortex damage because they project to an extrastriate visual area, and not because their terminals depart from the otherwise strict topographic representation of the lateral geniculate nucleus on to striate cortex.