Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;36(10):890-6.
doi: 10.1038/jp.2016.108. Epub 2016 Jul 21.

Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study

H Nakanishi  1 , A Uchiyama  1 , S Kusuda  1
Affiliations

Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study

H Nakanishi et al. J Perinatol. 2016 Oct.

Abstract

Objectives: To evaluate the impact of pulmonary hypertension (PH) on long-term growth and neurodevelopmental outcomes of extremely preterm infants with bronchopulmonary dysplasia (BPD).

Study design: A single-center retrospective cohort of preterm infants born at <28 weeks gestational age from 2000 to 2011 was evaluated at 3 years of age. Growth and neurodevelopmental outcomes were compared among 3 groups: non-BPD, BPD without PH and BPD with PH. BPD was defined according to oxygen demand at 36 weeks postmenstrual age. PH was diagnosed by echocardiography during the neonatal intensive care unit stay.

Results: Sixty-two infants without BPD, 60 with BPD without PH and 20 with BPD with PH were analyzed. Regardless of PH status, somatic growth was smaller in both BPD groups of infants than in non-BPD infants, with further reduction in the group having BPD with PH. Furthermore, a developmental quotient of <70 was more prevalent in the BPD infants with PH than in the BPD infants without PH (odds ratio (OR): 4.37; 95% confidence interval, CI: 1.16 to 16.5). Multivariate analysis demonstrated that BPD with PH was one of the independent perinatal risk factors for developmental quotient <70 at 3 years of age (OR: 4.94, 95% confidence interval: 1.06 to 24.1).

Conclusion: PH had an additional negative effect on long-term growth and neurodevelopmental outcomes of extremely preterm infants with BPD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart of the study infants evaluated. Among 209 infants at <28 weeks GA, 172 were classified into three groups: 72 non-BPD; 78 BPD without PH; 22 BPD with PH. Among those study infants, 142 were followed up until 3 years of age and were evaluated for long-term prognosis. BPD, bronchopulmonary dysplasia; GA, gestational age; PH, pulmonary hypertension.
See this image and copyright information in PMC

References

    1. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126: 443–456. - PMC - PubMed
    1. Itabashi K, Horiuchi T, Kusuda S, Kabe K, Itani Y, Nakamura T et al. Mortality rates for extremely low birth weight infants born in Japan in 2005. Pediatrics 2009; 123: 445–450. - PubMed
    1. Kusuda S, Fujimura M, Sakuma I, Aotani H, Kabe K, Itani Y et al. Morbidity and mortality of infants with very low birth weight in Japan: center variation. Pediatrics 2006; 118: e1130–e1138. - PubMed
    1. Kusuda S, Fujimura M, Uchiyama A, Totsu S, Matsunami K. Neonatal Research Network J. Trends in morbidity and mortality among very-low-birth-weight infants from 2003 to 2008 in Japan. Pediatr Res 2012; 72: 531–538. - PMC - PubMed
    1. An HS, Bae EJ, Kim GB, Kwon BS, Beak JS, Kim EK et al. Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Korean Circ J 2010; 40: 131–136. - PMC - PubMed

MeSH terms