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Case Reports
. 1978 Jul 12;43(1):85-9.
doi: 10.1007/BF00396482.

G6PD Vientiane: a new glucose-6-phosphate dehydrogenase variant with increased stability

A Kahn, M L North, D Cottreau, G Giron, J M Lang, F Oberling
Case Reports

G6PD Vientiane: a new glucose-6-phosphate dehydrogenase variant with increased stability

A Kahn et al. Hum Genet. .

Abstract

A new G6PD variant, called G6PD Vientiane, has been discovered in a patient from Laos. The characteristics of this variant are: mild enzyme deficiency (about 50% of the normal activity) in the granulocytes and the red cells, with normal G6PD-related antigen concentration; increased stability; normal Km glucose 6-phosphate and NADP+; increased inhibition constant by NADPH; decreased inhibition by ATP; slightly increased utilization of the substrate analogue; abnormal pH curve, with maximum activity at pH 9.5; slightly reduced starch gel electrophoretic migration. The implications of the molecular stability of a deficient mutant variant are discussed.

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