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Comment
. 2016 Jul 21;128(3):319-20.
doi: 10.1182/blood-2016-06-719898.

Synergy: karyotypes and mutations in CLL

Lynne V Abruzzo  1
Affiliations
Comment

Synergy: karyotypes and mutations in CLL

Lynne V Abruzzo. Blood. .

Abstract

In this issue of Blood, Herling et al present the first large, prospective clinical trial that integrates cytogenetic, next-generation sequencing (NGS), clinical, and laboratory data into a prognostic analysis. They demonstrate that karyotypic complexity is an independent prognostic factor of survival in chronic lymphocytic leukemia (CLL). They are also the first to show that mutations in KRAS or POT1 affect treatment response and survival after chemoimmunotherapy. Their results provide a strong rationale for incorporating the results of karyotypic and NGS analyses in clinical trial design and in routine practice.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Comment on

References

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