Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul 4:11:887-95.
doi: 10.2147/CIA.S103845. eCollection 2016.

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Rongtao Cui  1 , Lin Zhou  2 , Zuohong Li  2 , Qing Li  2 , Zhiming Qi  2 , Junyong Zhang  3
Affiliations

Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Rongtao Cui et al. Clin Interv Aging. .

Abstract

Objective: The aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment of the risk of osteoporosis.

Materials and methods: A total of 1,035 male and 3,953 female healthy volunteers (aged 41-95 years) were recruited by an open invitation. The basic information, including age, sex, height, weight, waistline, hipline, menstrual cycle, and medical history, were collected by a questionnaire survey and physical examination. Serum lipid profiles, BG, postprandial blood glucose, and glycosylated hemoglobin were obtained after 12 hours fasting. BMD in lumbar spine was measured by dual-energy X-ray absorptiometry scanning.

Results: The age-adjusted BMD in females was significantly lower than in males. With aging, greater differences of BMD distribution exist in elderly females than in males (P<0.001), and the fastigium of bone mass loss was in the age range from 51 to 55 in females and from 61 to 65 years in males. After adjustment for sex, there were significant differences in BMD among BMI-stratified groups in both males and females. The subjects with a BMI of <18.5 had a higher incidence of osteoporosis than BMI ≥18.5 in both sexes. BMD in type 2 diabetes mellitus with a BG of >7.0 mmol/L was lower than in people with BG of ≤7.0 mmol/L (P<0.001). People with serum high-density lipoprotein cholesterol levels of ≥1.56 mmol/L had a greater prevalence of osteoporosis compared with high-density lipoprotein cholesterol ≤1.55 mmol/L. Logistic regression with odds ratios showed that no association was found among total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, postprandial blood glucose and BMD.

Conclusion: The present study further confirmed that factors such as age, sex, weight, BMI, high-density lipoprotein cholesterol, and diabetes are significant predictors of osteoporosis in the Chinese people.

Keywords: BMI; blood glucose; osteoporosis; risk assessment; serum lipid profiles.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of age-related BMD changes between male and female in lumbar spine. Abbreviation: BMD, bone mineral density.
Figure 2
Figure 2
Comparison of age-related OP morbidity changes between male and female in lumbar spine. Abbreviation: OP, osteoporosis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wang Y, Tao Y, Hyman ME, Li J, Chen Y. Osteoporosis in China. Osteoporosis Int. 2009;20(10):1651–1662. - PubMed
    1. Lin X, Xiong D, Peng YQ, et al. Epidemiology and management of osteoporosis in the People’s Republic of China: current perspectives. Clin Interv Aging. 2015;10:1017–1033. - PMC - PubMed
    1. Cummings SR. Osteoporosis: Review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis – Status report. Osteoporosis Int. 1998;8:S1–S85. - PubMed
    1. Atsumi K, Kushida K, Okamoto S, Aoshima H. Bone mineral density at various sites for prediction of vertebral fractures in hemodialysis patients. J Bone Miner Res. 2001;16:S544–554.
    1. Karaguzel G, Holick MF. Diagnosis and treatment of osteopenia. Rev Endocr Metab Disord. 2010;11(4):237–251. - PubMed

MeSH terms