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Review
. 2016 Jun 21:7:248.
doi: 10.3389/fphys.2016.00248. eCollection 2016.

Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease

Jie Tao  1 , Zhen Lan  1 , Yunman Wang  1 , Hongya Hei  2 , Lulu Tian  2 , Wanma Pan  2 , Xuemei Zhang  2 , Wen Peng  1
Affiliations
Review

Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease

Jie Tao et al. Front Physiol. .

Abstract

Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.

Keywords: BK channels; glomerular filtration; mesangial cells; podocytes; β subunits.

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Figures

Figure 1
Figure 1
BK channels participated in the signal integration of podocytes and mesangial cells. (A) Hypothesized relation among TRPC6, BK, and SDs in podocyte. Podocyte BK participated in the cytoskeleton-related signal integration. (B) Hypothesized relation among VGCC and BK in mesangial cell. Mesangial BK participated in the signal integration of mesangial cell relaxion.
See this image and copyright information in PMC

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