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. 2016 Aug;12(2):928-932.
doi: 10.3892/ol.2016.4720. Epub 2016 Jun 15.

Sclerosing angiomatoid nodular transformation of the spleen: A case report and literature review

Tian-Bao Wang  1 , Bao-Guang Hu  2 , Da-Wei Liu  3 , Zhen-Hua Gao  4 , Han-Ping Shi  1 , Wen-Guang Dong  1
Affiliations

Sclerosing angiomatoid nodular transformation of the spleen: A case report and literature review

Tian-Bao Wang et al. Oncol Lett. 2016 Aug.

Abstract

Sclerosing angiomatoid nodular transformation (SANT) is a rare benign splenic vascular lesion. Since it was first defined in 2004, a total of 132 cases of SANT have been reported in ~50 studies in the English literature. However, it remains difficult to form a definitive pre-operative differential diagnosis of SANT compared with other splenic tumors or malignant lesions. The present study reports a pathologically proven case of SANT in a 29-year-old man who initially presented with left upper quadrant and back discomfort. The study also provides a review of the current knowledge on the condition, including the clinical profile, imaging features, cytological features, differential diagnosis and treatment of SANT. The most important distinguishing features of SANT are its typical vascular character and lack of other features that are typical of a granuloma. A splenectomy is required and the diagnosis is based on pathological analysis.

Keywords: diagnosis; sclerosing angiomatoid nodular transformation; spleen; treatment.

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Figures

Figure 1.
Figure 1.
CT scans of sclerosing angiomatoid nodular transformation. (A) Slightly low density lesion on a plain scanning CT image. (B) The CT value of the mass was clearly lower than that of the surrounding normal spleen on arterial phase-enhanced CT scanning. (C) The CT value of the mass remained lower than that of the surrounding spleen on portal venous-phase enhanced CT scanning. (D) The densities of the mass and the normal surrounding spleen were close on delayed enhanced CT scanning (D). CT, computed tomography.
Figure 2.
Figure 2.
Pathological examination of sclerosing angiomatoid nodular transformation. (A) Nodules were separated by fibrous or fibrosclerotic stroma (magnification, ×12.5). (B) Within the nodules, extravasated erythrocytes and hemosiderin pigment were plentiful. Immunohistochemical analysis documented positive expression of (C) CD8, (D) CD31 and (E) CD34 (magnification, ×100). CD, cluster of differentiation.
See this image and copyright information in PMC

References

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