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. 1989 May;4(4):552-9.
doi: 10.1016/0888-7543(89)90279-6.

Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease

N C Lan  1 , C Heinzmann, A Gal, I Klisak, U Orth, E Lai, J Grimsby, R S Sparkes, T Mohandas, J C Shih
Affiliations

Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease

N C Lan et al. Genomics. 1989 May.

Abstract

Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).

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