doi: 10.1016/0888-7543(89)90279-6.
Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease
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- PMID: 2744764
- DOI: 10.1016/0888-7543(89)90279-6
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Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease
Genomics.
1989 May.
Abstract
Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
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