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Comment
. 2016 Jul 21;63(2):181-183.
doi: 10.1016/j.molcel.2016.07.006.

Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation

Mario Leutert  1 , Deena M Leslie Pedrioli  2 , Michael O Hottiger  3
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Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation

Mario Leutert et al. Mol Cell. .
Free article

Abstract

In a recent issue of Science, Gibson et al. (2016) describe an in vitro chemical genetic approach that maps the specific ADP-ribosylation sites targeted by the ADP-ribosyltransferases PARP-1, PARP-2, and PARP-3 and demonstrate that PARP-1 regulates RNA polymerase II promoter-proximal pausing.

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