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Comparative Study
. 2016 Aug 17;34(37):4406-14.
doi: 10.1016/j.vaccine.2016.07.019. Epub 2016 Jul 19.

Adverse events following pandemic influenza A (H1N1) 2009 monovalent and seasonal influenza vaccinations during the 2009-2010 season in the active component U.S. military and civilians aged 17-44years reported to the Vaccine Adverse Event Reporting System

Barbara H Bardenheier  1 , Susan K Duderstadt  1 , Renata J M Engler  2 , Michael M McNeil  3
Affiliations
Comparative Study

Adverse events following pandemic influenza A (H1N1) 2009 monovalent and seasonal influenza vaccinations during the 2009-2010 season in the active component U.S. military and civilians aged 17-44years reported to the Vaccine Adverse Event Reporting System

Barbara H Bardenheier et al. Vaccine. .

Abstract

Background: No comparative review of Vaccine Adverse Event Reporting System (VAERS) submissions following pandemic influenza A (H1N1) 2009 and seasonal influenza vaccinations during the pandemic season among U.S. military personnel has been published.

Methods: We compared military vs. civilian adverse event reporting rates. Adverse events (AEs) following vaccination were identified from VAERS for adults aged 17-44years after pandemic (monovalent influenza [MIV], and seasonal (trivalent inactivated influenza [IIV3], live attenuated influenza [LAIV3]) vaccines. Military vaccination coverage was provided by the Department of Defense's Defense Medical Surveillance System. Civilian vaccination coverage was estimated using data from the National 2009 H1N1 Flu Survey and the Behavioral Risk Factor Surveillance System survey.

Results: Vaccination coverage was more than four times higher for MIV and more than twenty times higher for LAIV3 in the military than in the civilian population. The reporting rate of serious AE reports following MIV in service personnel (1.19 per 100,000) was about half that reported by the civilian population (2.45 per 100,000). Conversely, the rate of serious AE reports following LAIV3 among service personnel (1.32 per 100,000) was more than twice that of the civilian population. Although fewer military AEs following MIV were reported overall, the rate of Guillain-Barré Syndrome (GBS) (4.01 per million) was four times greater than that in the civilian population. (1.04 per million).

Conclusions: Despite higher vaccination coverage in service personnel, the rate of serious AEs following MIV was about half that in civilians. The rate of GBS reported following MIV was higher in the military.

Keywords: Pandemic influenza A H1N1 (2009) influenza vaccine; Vaccine safety.

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Conflict of interest statement

Conflict of interest

None of the authors has conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Distribution of diagnostic categories for VAERS reports received by December 31, 2010 for civilian individuals aged 17–44 years vaccinated with pandemic influenza A (H1N1) 2009 monovalent vaccine and/or seasonal influenza vaccine between August 1, 2009 and July 31, 2010.
Fig. 2.
Fig. 2.
Distribution of diagnostic categories for VAERS reports received by December 31, 2010 for confirmed active military individuals aged 17–44 years vaccinated with pandemic influenza A (H1N1) 2009 monovalent vaccine and/or seasonal influenza vaccine between August 1, 2009 and July 31, 2010.
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References

    1. Centers for Disease Control and Prevention. Safety of influenza A (H1N1) 2009 monovalent vaccines – United States, October 1-November 24, 2009. MMWR Morbidity and mortality weekly report, vol. 58, 2009, pp. 1351–1356. - PubMed
    1. Mayet A, Ligier C, Gache K, Manet G, Nivoix P, Dia A, et al. Adverse events following pandemic influenza vaccine Pandemrix(R) reported in the French military forces–2009–2010. Vaccine 2011;29:2576–81. - PubMed
    1. Banzhoff A, Haertel S, Praus M. Passive surveillance of adverse events of an MF59-adjuvanted H1N1v vaccine during the pandemic mass vaccinations. Human Vaccines 2011;7:539–48. - PubMed
    1. Vellozzi C, Broder KR, Haber P, Guh A, Nguyen M, Cano M, et al. Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the Vaccine Adverse Event Reporting System, United States, October 1, 2009-January 31, 2010. Vaccine 2010;28:7248–55. - PubMed
    1. Halsey NA, Griffioen M, Dreskin SC, Dekker CL, Wood R, Sharma D, et al. Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: reports to VAERS. Vaccine 2013;31:6107–12. - PubMed

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