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Guideline
. 2016 Dec 1;34(49):6027-6037.
doi: 10.1016/j.vaccine.2016.03.040. Epub 2016 Jul 19.

Neonatal death: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Jayani Pathirana  1 , Flor M Muñoz  2 , Victoria Abbing-Karahagopian  3 , Niranjan Bhat  4 , Tara Harris  5 , Ambujam Kapoor  6 , Daniel L Keene  7 , Alexandra Mangili  8 , Michael A Padula  9 , Stephen L Pande  10 , Vitali Pool  11 , Farshad Pourmalek  12 , Frederick Varricchio  13 , Sonali Kochhar  14 , Clare L Cutland  15 ; Brighton Collaboration Neonatal Death Working Group
Affiliations
Guideline

Neonatal death: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Jayani Pathirana et al. Vaccine. .

Abstract

More than 40% of all deaths in children under 5 years of age occur during the neonatal period: the first month of life. Immunization of pregnant women has proven beneficial to both mother and infant by decreasing morbidity and mortality. With an increasing number of immunization trials being conducted in pregnant women, as well as roll-out of recommended vaccines to pregnant women, there is a need to clarify details of a neonatal death. This manuscript defines levels of certainty of a neonatal death, related to the viability of the neonate, who confirmed the death, and the timing of the death during the neonatal period and in relation to immunization of the mother.

Keywords: Adverse event; Case definition; Guidelines; Maternal immunization; Neonatal death.

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Figures

Fig. 1
Fig. 1
Neonatal mortality rate in 100,000, age-standardized, both sexes, World Health Organization regions, 2013/Institute for Health Metrics and Evaluation (IHME). GBD Compare. Seattle, WA: IHME, University of Washington, 2015. Available from http://ihmeuw.org/3qjx (accessed 21.12.15).
Fig. 2
Fig. 2
Neonatal mortality, percent of total deaths age-standardized, both sexes, World Health Organization regions, 2013/Institute for Health Metrics and Evaluation (IHME). GBD Compare. Seattle, WA: IHME, University of Washington, 2015. Available from http://ihmeuw.org/3qjy (accessed 21.12.15).
Fig. 3
Fig. 3
Algorithm for the classification of neonatal death.
See this image and copyright information in PMC

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