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Observational Study
. 2016 Jul 22:16:118.
doi: 10.1186/s12886-016-0272-7.

Assessment of the prevalence and risk factors of ophthalmoplegia among diabetic patients in a large national diabetes registry cohort

Eman S Al Kahtani  1 , Rajiv Khandekar  1 , Khalid Al-Rubeaan  2   3 , Amira M Youssef  4 , Heba M Ibrahim  4 , Ahmed H Al-Sharqawi  4
Affiliations
Observational Study

Assessment of the prevalence and risk factors of ophthalmoplegia among diabetic patients in a large national diabetes registry cohort

Eman S Al Kahtani et al. BMC Ophthalmol. .

Abstract

Background: There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients.

Methods: This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases. Demographic, clinical, and biochemical parameters were studied and STROBE guidelines were used to design and report the results of this study.

Results: The overall prevalence of ophthalmoplegia cases was 0.32 %, further distributed into: 53.11 %, 36.36 %, and 2.8 % for cranial nerves VI, III, IV palsies respectively. Ophthalmoplegic cases were predominantly type 2 diabetic males with older age and longer diabetes duration. The most important and significant risk factors were age ≥ 45 years, diabetes duration ≥ 10 years, male gender and presence of retinopathy and nephropathy.

Conclusions: Ophthalmoplegia is a rare entity associated mainly with type 2 diabetes. Clinicians have to consider its risk factors when screening or planning for prevention of this condition.

Keywords: Diabetes mellitus; III cranial nerve palsy; IV cranial nerve palsy; Ophthalmoplegia; VI cranial nerve palsy.

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Figures

Fig. 1
Fig. 1
Flow diagram for ophthalmoplegia cases identified among patients ≥ 18 years during the period from 2000 to 2010 using the Saudi National Diabetes registry database
Fig. 2
Fig. 2
Univariate analysis of the different ophthalmoplegia risk factors
See this image and copyright information in PMC

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References

    1. Bruce BB, Biousse V, Newman NJ. Third nerve palsies. Semin Neurol. 2007;27(3):257–68. doi: 10.1055/s-2007-979681. - DOI - PubMed
    1. El Mansouri Y, Zaghloul K, Amraoui A. Oculomotor paralyses in the course of diabetes--concerning 12 cases. J Fr Ophtalmol. 2000;23(1):14–8. - PubMed
    1. Richards BW, Jones FR, Younge BR. Causes and prognosis in 4,278 cases of paralysis of the oculomotor, trochlear, and abducens cranial nerves. Am J Ophthalmol. 1992;113(5):489–96. doi: 10.1016/S0002-9394(14)74718-X. - DOI - PubMed
    1. Greco D, Gambina F, Pisciotta M, Abrignani M, Maggio F. Clinical characteristics and associated comorbidities in diabetic patients with cranial nerve palsies. J Endocrinol Invest. 2012;35(2):146–9. - PubMed
    1. Greco D, Gambina F, Maggio F. Ophthalmoplegia in diabetes mellitus: a retrospective study. Acta Diabetol. 2009;46(1):23–6. doi: 10.1007/s00592-008-0053-8. - DOI - PubMed

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