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. 2017 Mar;98(3):480-486.
doi: 10.1016/j.apmr.2016.06.019. Epub 2016 Jul 20.

Negative Neurodynamic Tests Do Not Exclude Neural Dysfunction in Patients With Entrapment Neuropathies

Larissa T Baselgia  1 , David L Bennett  2 , Robert M Silbiger  3 , Annina B Schmid  4
Affiliations

Negative Neurodynamic Tests Do Not Exclude Neural Dysfunction in Patients With Entrapment Neuropathies

Larissa T Baselgia et al. Arch Phys Med Rehabil. 2017 Mar.

Abstract

Objective: To examine differences in somatosensory phenotypes of patients with positive and negative neurodynamic tests and compare these with healthy participants.

Design: Case-control study.

Setting: University department.

Participants: Patients with electrodiagnostically confirmed carpal tunnel syndrome (CTS) (n=53) and people without CTS (n=26) participated in this study (N=79). Patients with CTS were subgrouped according to the results of the upper limb neurodynamic tests biasing the median nerve into patients with positive or negative neurodynamic tests.

Interventions: Not applicable.

Main outcome measure: All participants underwent quantitative sensory testing in the median innervated territory of their hand.

Results: Only 46% of patients with CTS had positive neurodynamic tests. No differences were identified between groups for pain thresholds (P>.247). However, patients with CTS had increased mechanical (P<.0001) and thermal detection thresholds (P<.0001) compared with people without CTS. Patients with negative neurodynamic tests had a more pronounced vibration detection deficit (mean, 7.43±0.59) than people without CTS (mean, 7.89±0.22; P=.001). Interestingly, warm detection was the only domain differentiating positive (mean, 4.03°C±2.18°C) and negative neurodynamic test groups (6.09°C±3.70°C, P=.032), with patients with negative neurodynamic tests demonstrating increased loss of function.

Conclusions: Patients with negative neurodynamic tests seem to have a more severe dysfunction of the unmyelinated fiber population. Our findings suggest that neurodynamic tests should not be used in isolation to judge neural involvement. Rather, they should be interpreted in the context of loss of function tests of the small fiber domain.

Keywords: Carpal tunnel syndrome; Diagnosis; Nerve compression syndromes; Neurologic examination; Peripheral nerve injuries; Rehabilitation.

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Figures

Fig 1
Fig 1
Somatosensory phenotype. The mean z score sensory profiles are shown of participants without CTS (green), patients with ULNTpos (red), and patients with ULNTneg (orange). (A) QST domains reflecting detection thresholds. (B) Pain thresholds. ∗Significance compared with participants without CTS. #Significance between CTS groups. Error bars represent SDs. Abbreviations: TSL, thermal sensory limen; ULNTneg, negative neurodynamic tests; ULNTpos, positive neurodynamic tests; WUR, wind up ratio.
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References

    1. Butler D.S. Neurodynamics. In: NOIGroup-Publications, editor. The sensitive nervous system. NOIgroup Publications; Unley DC: 2000. pp. 97–126.
    1. Urban L.M. The straight-leg-raising test: a review*. J Orthop Sports Phys Ther. 1981;2:117–133. - PubMed
    1. Elvey R.L. Brachial plexus tension tests and the pathoanatomical origin of arm pain. In: Dewhurst D., Glasgow E.F., Tehan P., Ward A.R., editors. Aspects of Manipulative Therapy. Proceedings of a Multidisciplinary Conference on Manipulative Therapy. Churchill Livingstone; Melbourne (Australia). New York: 1979 Aug. pp. 105–110.
    1. Lohman C.M., Gilbert K.K., Sobczak S. 2015 Young Investigator Award Winner: cervical nerve root displacement and strain during upper limb neural tension testing: part 1: a minimally invasive assessment in unembalmed cadavers. Spine (Phila Pa 1976) 2015;40:793–800. - PubMed
    1. Vanti C., Bonfiglioli R., Calabrese M., Marinelli F., Violante F.S., Pillastrini P. Relationship between interpretation and accuracy of the upper limb neurodynamic test 1 in carpal tunnel syndrome. J Manipulative Physiol Ther. 2012;35:54–63. - PubMed

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