Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;37(11):1823-1829.
doi: 10.1007/s10072-016-2628-4. Epub 2016 Jul 23.

Elevated fibrinogen levels in neuromyelitis optica is associated with severity of disease

Ya Zhang  1 , Xiaomei Zhang  1 , Dongsheng Liu  2 , Honghao Wang  3 , Suyue Pan  1 , Dongmei Wang  1 , Xiong Chen  1
Affiliations

Elevated fibrinogen levels in neuromyelitis optica is associated with severity of disease

Ya Zhang et al. Neurol Sci. 2016 Nov.

Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system. In this study, the important role of fibrinogen in demyelination diseases was investigated. Plasma prothrombin time (PT), activated partial thrombin time (APTT), thrombin time (TT), fibrinogen, were measured among 189 patients with MS/NMO and 80 non-inflammatory neurological disease subjects as a control group. The Expanded Disability Status Scale (EDSS) was used to measure neurological impairment and disability of MS/NMO group. Fibrinogen levels were elevated in NMO and MS groups comparing with control ones, which was statistically associated with the severity of disease. Our results may lead to a better understanding of the etiopathogenesis of MS/NMO and contribute to prospects for preventions and treatments.

Keywords: Axonal destruction; Demyelination disease; Fibrinogen; Microglia; Multiple sclerosis; Neuromyelitis optica.

PubMed Disclaimer

References

    1. Mol Interv. 2004 Jun;4(3):163-76 - PubMed
    1. J Cell Biol. 2000 May 29;149(5):1157-66 - PubMed
    1. J Biol Chem. 1998 Aug 28;273(35):22519-27 - PubMed
    1. Cell. 1988 May 20;53(4):505-18 - PubMed
    1. Nat Commun. 2012;3:1227 - PubMed

LinkOut - more resources