Research that Guides Clinical Decisions
- PMID: 27450497
- DOI: 10.1016/j.jid.2016.04.031
Research that Guides Clinical Decisions
Abstract
The centerpiece of evidence-based medicine is the randomized controlled trial, a rigorous experiment. We use the study by Roozeboom et al. to illustrate how research guides clinical decisions. We describe levels of evidence, review criteria for assessing a trial regarding noninferiority of a therapy, and discuss challenges for evidence-based medicine in guiding care precisely targeted to an individual patient.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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Three-Year Follow-Up Results of Photodynamic Therapy vs. Imiquimod vs. Fluorouracil for Treatment of Superficial Basal Cell Carcinoma: A Single-Blind, Noninferiority, Randomized Controlled Trial.J Invest Dermatol. 2016 Aug;136(8):1568-1574. doi: 10.1016/j.jid.2016.03.043. Epub 2016 Apr 23. J Invest Dermatol. 2016. PMID: 27113429 Clinical Trial.
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