Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep:46:103-109.
doi: 10.1016/j.etap.2016.07.004. Epub 2016 Jul 14.

Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin

Jing Liu  1 , Shuli Man  2 , Jing Li  3 , Yang Zhang  3 , Xin Meng  3 , Wenyuan Gao  4
Affiliations

Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin

Jing Liu et al. Environ Toxicol Pharmacol. 2016 Sep.

Abstract

Rhizoma Paridis saponin (RPS) had been regarded as the main active components responsible for the anti-tumor effects of the herb Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. In the present research, we set up a rat model of diethylnitrosamine (DEN) induced hepatoma to evaluate antitumor effect of RPS. After 20 weeks treatment, rats were sacrificed to perform histopathological examinations, liver function tests, oxidative stress assays and so forth. As a result, DEN-induced hepatoma formation. RPS alleviated levels of liver injury through inhibiting liver tissues of malondialdehyde (MDA) and nitric oxide (NO) formation, increasing superoxide dismutases (SOD) production, and up-regulating expression of GST-α/μ/π in DEN-induced rats. All in all, RPS would be a potent agent inhibiting chemically induced liver cancer in the prospective application.

Keywords: Diethylnitrosamine; Hpatoma; Oxidative stress; Rhizoma paridis saponin.

PubMed Disclaimer

MeSH terms

LinkOut - more resources