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. 2016 Jul 22;5(7):e003328.
doi: 10.1161/JAHA.116.003328.

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Jieli Lu  1 , Yiming Mu  2 , Qing Su  3 , Lixin Shi  4 , Chao Liu  5 , Jiajun Zhao  6 , Lulu Chen  7 , Qiang Li  8 , Tao Yang  9 , Li Yan  10 , Qin Wan  11 , Shengli Wu  12 , Yan Liu  13 , Guixia Wang  13 , Zuojie Luo  14 , Xulei Tang  15 , Gang Chen  16 , Yanan Huo  17 , Zhengnan Gao  18 , Zhen Ye  19 , Youmin Wang  20 , Guijun Qin  21 , Huacong Deng  22 , Xuefeng Yu  23 , Feixia Shen  24 , Li Chen  25 , Liebin Zhao  1 , Jichao Sun  1 , Wanwan Sun  1 , Tiange Wang  1 , Rui Du  1 , Lin Lin  1 , Meng Dai  1 , Yu Xu  1 , Min Xu  1 , Yufang Bi  1 , Shenghan Lai  26 , Donghui Li  27 , Weiqing Wang  28 , Guang Ning  1 ; REACTION Study Group
Collaborators, Affiliations

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Jieli Lu et al. J Am Heart Assoc. .

Abstract

Background: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.

Methods and results: This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for coronary heart disease (CHD), and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer-assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m(2)), those with decreased eGFR (75-89, 60-74, and <60 mL/min per 1.73 m(2)) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10-year Framingham risk for CHD and 10-year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60-89 mL/min per 1.73 m(2)).

Conclusions: Even mildly reduced eGFR (under 90 mL/min per 1.73 m(2)) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.

Keywords: Framingham Risk Score; atherosclerotic cardiovascular diseases; cardiovascular diseases; estimated glomerular filtration rate; reduced kidney function.

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Figures

Figure 1
Figure 1
Association between kidney function and cardiometabolic risk factors. Prevalence of obesity, diabetes mellitus, hypertension, and dyslipidemia in Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by estimated glomerular filtration rate (eGFR) status in men (A) and women (B). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
Figure 2
Figure 2
A, Distribution of estimated 10‐year Framingham risk for coronary heart disease (CHD) in the CVD and diabetes mellitus–free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and estimated glomerular filtration rate (eGFR) groups (N=181 683). (B) Distribution of estimated 10‐year risk for a first hard atherosclerotic cardiovascular diseases (ASCVD) event in the CVD‐free Chinese adults ages 40 to 79 (REACTION 2011–2012), stratified by sex and eGFR groups (N=225 005). REACTION indicates Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.
See this image and copyright information in PMC

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