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. 2016 Aug 5;18(15):3766-9.
doi: 10.1021/acs.orglett.6b01783. Epub 2016 Jul 25.

Silanediol-Catalyzed Chromenone Functionalization

Andrea M Hardman-Baldwin  1 , Michael D Visco  1 , Joshua M Wieting  1 , Charlotte Stern  1 , Shin-Ichi Kondo  1 , Anita E Mattson  1
Affiliations

Silanediol-Catalyzed Chromenone Functionalization

Andrea M Hardman-Baldwin et al. Org Lett. .

Abstract

Promising levels of enantiocontrol are observed in the silanediol-catalyzed addition of silyl ketene acetals to benzopyrylium triflates. This rare example of enantioselective, intermolecular chromenone functionalization with carbonyl-containing nucleophiles has potential applications in the synthesis of bioactive chromanones and tetrahydroxanthones.

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