Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 22:3:91-7.
doi: 10.1016/j.dadm.2016.05.004. eCollection 2016.

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Brianne M Bettcher  1 , Ryan Fitch  2 , Matthew J Wynn  2 , Matthew A Lalli  3 , Jonathan Elofson  2 , Laura Jastrzab  2 , Laura Mitic  2 , Zachary A Miller  2 , Gil D Rabinovici  2 , Bruce L Miller  2 , Aimee W Kao  2 , Kenneth S Kosik  3 , Joel H Kramer  2
Affiliations

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Brianne M Bettcher et al. Alzheimers Dement (Amst). .

Abstract

Introduction: MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.

Methods: MCP-1 and eotaxin-1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained.

Results: An interaction was noted between MCP-1 and eotaxin-1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non-chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains.

Discussion: These results suggest a potentially selective role for MCP-1 and eotaxin-1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

Keywords: Chemokines; Episodic memory; Inflammation; Neuroimaging; Neuropsychology.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
The figure displays eotaxin and MCP-1 levels as a function of MCI and Alzheimer's disease phenotypes. Abbreviations: AD-Mem, amnestic phenotype; lvPPA, logopenic variant of primary progressive aphasia phenotype; PCA, posterior cortical atrophy phenotype. *Significant between group difference, P <.05.
Fig. 2
Fig. 2
The figure demonstrates the relationship between MCP-1 and memory as a function of eotaxin-1 levels. The Verbal and Visual Memory Factory Score Residual is the memory factor score accounting for demographics and CDR.
See this image and copyright information in PMC

References

    1. Heneka M.T., Carson M.J., El Khoury J., Landreth G.E., Brosseron F., Feinstein D.L. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14:388–405. - PMC - PubMed
    1. Bettcher B.M., Kramer J.H. Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase. 2013;19:182–200. - PMC - PubMed
    1. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun. 2011;25:181–213. - PubMed
    1. Baruch K., Ron-Harel N., Gal H., Deczkowska A., Shifrut E., Ndifon W. CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci U S A. 2013;110:2264–2269. - PMC - PubMed
    1. Lalli M.A., Bettcher B.M., Arcila M.L., Garcia G., Guzman C., Madrigal L. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. Mol Psychiatry. 2015;20:1294–1300. - PMC - PubMed