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Meta-Analysis
. 2016 Jul 26:6:30437.
doi: 10.1038/srep30437.

Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis

Jian Xiao  1 , Bixiu He  1 , Yong Zou  1 , Xi Chen  2 , Xiaoxiao Lu  1 , Mingxuan Xie  1 , Wei Li  1 , Shuya He  3 , Shaojin You  4 , Qiong Chen  1
Affiliations
Meta-Analysis

Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis

Jian Xiao et al. Sci Rep. .

Abstract

The prognostic value of forkhead box protein P1 (FOXP1) protein expression in tumors remains controversial. Therefore, we conducted a systematic review and meta-analysis, searching the PubMed, Embase and Web of Science databases to identify eligible studies. In total, we analyzed 22 articles that examined 9 tumor types and included 2468 patients. Overall, decreased expression of FOXP1 protein was associated with favorable overall survival (OS) in lymphoma patients (HR = 0.38, 95%CI: 0.30-0.48, p < 0.001). In patients with solid tumors, decreased FOXP1 expression correlated with unfavorable OS (HR = 1.82, 95%CI: 1.18-2.83, p = 0.007). However, when FOXP1 protein expression was nuclear, decreased expression was also associated with favorable OS (HR = 0.53, 95%CI: 0.32-0.86, p = 0.011). Furthermore, decreased FOXP1 expression resulted in the best OS in patients with mucosa-associated lymphoid tissue (MALT) lymphomas (HR = 0.26, 95%CI: 0.11-0.59, p = 0.001), but the worst OS was observed in non-small cell lung cancer (NSCLC) patients (HR = 3.11, 95%CI: 1.87-5.17, p < 0.001). In addition, decreased FOXP1 expression was significantly correlated with an unfavorable relapse-free survival (RFS) in breast cancer patients (HR = 1.93, 95%CI: 1.33-2.80, p = 0.001).

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Figures

Figure 1
Figure 1. Flow diagram for study identification.
Figure 2
Figure 2. Forest plot for the relationships between decreased FOXP1 protein expression and OS in all tumor patients included in this meta-analysis.
Figure 3
Figure 3. Sensitivity analysis for the meta-analysis of OS in all tumor patients included in this meta-analysis.
Figure 4
Figure 4. Forest plot for the relationships between decreased FOXP1 protein expression and OS in lymphoma patients.
Figure 5
Figure 5. Forest plot for the relationships between decreased FOXP1 protein expression and OS in patients with solid tumors.
Figure 6
Figure 6. Forest plot for the relationships between decreased FOXP1 protein expression and CSS/DFS/FFS/PFS/RFS.
Figure 7
Figure 7
(a) Begg’s funnel plot of publication bias for meta-analysis of OS in all tumor patients included in this study; (b) Begg’s funnel plot of publication bias for meta-analysis of OS in patients with lymphomas; (c) Begg’s funnel plot of publication bias for meta-analysis of OS in patients with solid tumors.
See this image and copyright information in PMC

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