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. 2016 Aug;39(8):1299-306.
doi: 10.2337/dc15-2727.

Role of Glycated Proteins in the Diagnosis and Management of Diabetes: Research Gaps and Future Directions

Kerry J Welsh  1 , M Sue Kirkman  2 , David B Sacks  3
Affiliations

Role of Glycated Proteins in the Diagnosis and Management of Diabetes: Research Gaps and Future Directions

Kerry J Welsh et al. Diabetes Care. 2016 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Formation of glycated protein. A reversible interaction between a primary amino group (depicted as NH2) of a protein and the carbonyl group of d-glucose yields a labile intermediate, called a Schiff base. This can undergo a slow and spontaneous Amadori rearrangement to form a stable ketoamine. HbA1c is formed if glucose attaches to the N-terminal valine of the β-chain of hemoglobin. If the glucose attaches to proteins in the plasma, fructosamine or glycated albumin results. RBC, red blood cell.
Figure 2
Figure 2
Progressive increase in HbA1c testing over time. The number of clinical laboratories enrolled in proficiency testing surveys from the College of American Pathologists from 1993 to 2015 is depicted. Data used with permission from the College of American Pathologists.
See this image and copyright information in PMC

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References

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