Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov 15;10(6):902-909.
doi: 10.5009/gnl15340.

Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm

Ji Young Lee  1 , Hye Won Park  1 , Ji Young Choi  1 , Jong-Soo Lee  1 , Ja Eun Koo  1 , Eun Ju Chung  1 , Hye-Sook Chang  1 , Jaewon Choe  1 , Dong-Hoon Yang  2 , Seung-Jae Myung  2 , Hwoon-Yong Jung  2 , Suk-Kyun Yang  2 , Jeong-Sik Byeon  2
Affiliations

Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm

Ji Young Lee et al. Gut Liver. .

Abstract

Background/aims: Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. pylori infection status, AG and advanced CRN.

Methods: This cross-sectional study investigated the relationship between the presence of serum anti-H. pylori IgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy.

Results: A total of 316 participants (5.0%) had advanced CRN. H. pylori seropositivity was 61.3%. In a univariate analysis, the presence of H. pylori infection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001). H. pylori infection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023). H. pylori-related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereas H. pylori infection without AG was not.

Conclusions: H. pylori infection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those with H. pylori-positive AG.

Keywords: Atrophy; Gastritis; Helicobacter pylori; Neoplasms.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart of the study population. GI, gastrointestinal.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum; IARC Working Group on the evaluation of carcinogenic risks to humans; Lyon. 7–14 June 1994; 1994. pp. 1–241. - PMC - PubMed
    1. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030–3044. doi: 10.1002/ijc.21731. - DOI - PubMed
    1. Roubaud Baudron C, Franceschi F, Salles N, Gasbarrini A. Extragastric diseases and Helicobacter pylori. Helicobacter. 2013;18( Suppl 1):44–51. doi: 10.1111/hel.12077. - DOI - PubMed
    1. Selgrad M, Bornschein J, Rokkas T, Malfertheiner P. Helicobacter pylori: gastric cancer and extragastric intestinal malignancies. Helicobacter. 2012;17( Suppl 1):30–35. doi: 10.1111/j.1523-5378.2012.00980.x. - DOI - PubMed
    1. Meucci G, Tatarella M, Vecchi M, et al. High prevalence of Helicobacter pylori infection in patients with colonic adenomas and carcinomas. J Clin Gastroenterol. 1997;25:605–607. doi: 10.1097/00004836-199712000-00011. - DOI - PubMed

MeSH terms