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. 2016 Jun;13(2):236-47.
doi: 10.20892/j.issn.2095-3941.2016.0024.

Genetic and molecular changes in ovarian cancer

Robert L Hollis  1 , Charlie Gourley  1
Affiliations

Genetic and molecular changes in ovarian cancer

Robert L Hollis et al. Cancer Biol Med. 2016 Jun.

Erratum in

Abstract

Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications. However, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.

Keywords: Ovarian cancer; histological subtypes; molecular genetics; molecular subgrouping; ovary.

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Figures

Figure1
Figure1
Common molecular events identified in HGS OC, including genetic and epigenetic defects in HRR pathway components (right).
See this image and copyright information in PMC

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