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Case Reports
. 2016 Oct;18(5):773-776.
doi: 10.1111/tid.12579. Epub 2016 Sep 7.

Viral load and ganciclovir (GCV) concentration in cerebrospinal fluid of patients successfully treated with GCV or valGCV for human herpesvirus 6 encephalitis/myelitis following umbilical cord blood transplantation

D Morita  1 , K Hirabayashi  1 , Y Katsuyama  2 , H Morokawa  1 , M Motobayashi  1 , T Kurata  1 , T Shigemura  1 , M Tanaka  1 , Y Inaba  1 , K Koike  1 , Y Nakazawa  3
Affiliations
Case Reports

Viral load and ganciclovir (GCV) concentration in cerebrospinal fluid of patients successfully treated with GCV or valGCV for human herpesvirus 6 encephalitis/myelitis following umbilical cord blood transplantation

D Morita et al. Transpl Infect Dis. 2016 Oct.

Abstract

We describe successful treatment of 3 cases of human herpesvirus 6 (HHV-6) encephalitis/myelitis following cord blood transplantation (CBT). Ganciclovir (GCV) (10 mg/kg/day) reduced HHV-6 load to undetectable levels in cerebrospinal fluid (CSF). Early dose reduction in the presence of HHV-6 detectable in CSF resulted in an increased HHV-6 load. GCV was capably shifted to valganciclovir (VGCV) with an almost equivalent concentration. GCV/VGCV may be effective for HHV-6 encephalitis/myelitis after CBT, although HHV-6 load in CSF should be monitored.

Keywords: HHV-6; cerebrospinal fluid; cord blood transplantation; encephalitis; ganciclovir; valganciclovir.

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