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. 2016 Sep;32(9):887-93.
doi: 10.1007/s00383-016-3940-z. Epub 2016 Jul 26.

Risk factors and prevention for surgical intestinal disorders in extremely low birth weight infants

Masaya Yamoto  1 , Yusuke Nakazawa  2 , Koji Fukumoto  3 , Hiromu Miyake  3 , Hideaki Nakajima  3 , Akinori Sekioka  3 , Akiyoshi Nomura  3 , Kei Ooyama  3 , Yutaka Yamada  3 , Katsushi Nogami  2 , Yuko Van  2 , Chisako Furuta  2 , Reiji Nakano  2 , Yasuhiko Tanaka  2 , Naoto Urushihara  3
Affiliations

Risk factors and prevention for surgical intestinal disorders in extremely low birth weight infants

Masaya Yamoto et al. Pediatr Surg Int. 2016 Sep.

Abstract

Purpose: Surgical intestinal disorders (SID), such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in extremely low birth weight (ELBW, birth weight <1000 g) infants. From 2010, we performed enteral antifungal prophylaxis (EAP) in ELBWI to prevent for SID. The aim of this study was to identify disease-specific risk factors and to evaluate the efficacy of prevention for SID in ELBW infants.

Methods: A retrospective chart review of all consecutive patients between January 2006 and March 2015, which included 323 ELBW infants who were admitted to Shizuoka Children's Hospital, was conducted.

Results: The number of infants with NEC, FIP, and MRI was 9, 12, and 13, respectively; 28 in 323 ELBW infants died. The control group defined the cases were not SID. In-hospital mortality was higher in infants with NEC relative to those in the control group. On logistic regression analysis, low gestational age and cardiac malformations were associated with increased risk of NEC. IUGR were associated with increased risk of MRI. EAP decreased risk of NEC and FIP. Low gestational weight and NEC were associated with increased risk of death.

Conclusion: Survival to hospital discharge after operation for NEC in ELBW infants remains poor. EAP decreased risk of NEC and FIP in ELBW infants.

Keywords: Enterally antifungal prophylaxis; Extremely low birth weight infants; Focal intestinal perforation; Meconium-related ileus; Necrotizing enterocolitis; Surgical intestinal disorders.

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