Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Apr-Jun;12(2):509-14.
doi: 10.4103/0973-1482.154056.

Oxaliplatin-induced acute thrombocytopenia

Gokmen Umut Erdem  1 , Mutlu Dogan  1 , Nebi Serkan Demirci  1 , Nurullah Zengin  1
Affiliations
Free article
Review

Oxaliplatin-induced acute thrombocytopenia

Gokmen Umut Erdem et al. J Cancer Res Ther. 2016 Apr-Jun.
Free article

Abstract

Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are neurotoxicity (peripheral neuropathy), myelosuppression with moderate thrombocytopenia and gastrointestinal toxicity (diarrhea). Thrombocytopenia might be related to myelosuppression and/or drug-induced immune thrombocytopenia (DIIT). In here, oxaliplatin-induced thrombocytopenia is discussed with review of the literature.

PubMed Disclaimer

MeSH terms

LinkOut - more resources