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Comment
. 2016 Aug;152(2):257-61.
doi: 10.1093/toxsci/kfw113.

From the Editor's Desk, Editor's Highlights, Letters to the Editor

No authors listed
Comment

From the Editor's Desk, Editor's Highlights, Letters to the Editor

No authors listed. Toxicol Sci. 2016 Aug.
No abstract available

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Figures

FIG. 1
FIG. 1
(A) Diagram of a sagittal section at lateral ∼1.90 mm with the approximate location of the displayed XRF scan indicated by the cyan box. (B) Summary of Cu concentrations in the SVZ and RMS for control (white) and treated (gray) groups (mean ± standard deviation). Concentrations are shown for both the whole ROI (left) and thresholded regions (right). * P < 0.05 for treated versus control. Line: 8.5 μg/g threshold. n = 5 rats per group. (C) Typical Cu XRF image with different brain regions labeled; the scale bar for Cu concentrations is given in μg/g. Example of SVZ and RMS selection prior to widening (D) and after widening by ±3 pixels in the 4 cardinal directions (E). Note that widening overestimates the spatial dimensions of both the RMS and SVZ, thereby including neighboring structures (i.e. STR, CC, and/or LV), while removing the selection bias of the experimenter. (F) Results after applying a concentration threshold of 8.5 μg/g. Given numbers are in μg/g. Abbreviations: Ctx, cortex; CC, corpus callosum; LV, lateral ventricle; RMS, rostral migratory stream; STR, straitum; SVZ, subventricular zone. Scale bar: 1 mm.
FIG. 2
FIG. 2
(A) Representative Ki67 stain of the SVZ and RMS for a control rat and (B) representative Ki67 stain for a Mn-treated rat. Magnification 10×. (C) High magnification (40×) view of the RMS in a control rodent. (D) Quantitation of neurogenesis (mean ± standard deviation) by Ki67+ cell density in the SVZ and RMS.
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