Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Jun 10;9(2):305-11.
doi: 10.1159/000446694. eCollection 2016 May-Aug.

Small Cell Carcinoma of the Ovary (Hypercalcemic Type): Malignant Rhabdoid Tumor

Peter Kascak  1 , Michal Zamecnik  2 , Branislav Bystricky  3
Affiliations
Case Reports

Small Cell Carcinoma of the Ovary (Hypercalcemic Type): Malignant Rhabdoid Tumor

Peter Kascak et al. Case Rep Oncol. .

Abstract

We present a rare case of malignant rhabdoid tumor (ovarian small cell carcinoma of hypercalcemic type) in a 24-year-old female with fulminant course. Clinically, hypercalcemia was not found at the time of primary diagnosis. However, it appeared later during the course of tumor progression. Histologically, the tumor showed classical features of small cell carcinoma of hypercalcemic type. Therapy included radical surgery with adjuvant chemotherapy. Despite this intensive therapy, the disease recurred and the patient died 10 months after the diagnosis. We discuss the diagnosis and therapy of this tumor, as well as its recent classification as malignant rhabdoid tumor.

Keywords: Chemotherapy; Immunohistochemistry; Malignant rhabdoid tumor; Ovarian cancer; Small cell carcinoma of hypercalcemic type.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Coronal CT scan before surgery.
Fig. 2
Fig. 2
Histological features of SCCOHT. Highly atypical small cells arranged in a solid pattern, with follicle-like space (left). Hematoxylin and eosin. ×400.
Fig. 3
Fig. 3
Axial CT scan: relapse of disease 5 months after adjuvant chemotherapy.
See this image and copyright information in PMC

References

    1. Young RH, Oliva E, Scully RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol. 1994;18:1102–1116. - PubMed
    1. Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of the ovary with hypercalcemia: a report of eleven cases. Cancer. 1982;49:188–197. - PubMed
    1. Clement PB. Selected miscellaneous ovarian lesions: small cell carcinomas, mesothelial lesions, mesenchymal and mixed neoplasms, and non-neoplastic lesions. Mod Pathol. 2005;18(suppl 2):S113–S129. - PubMed
    1. Foulkes WD, Clarke BA, Hasselblatt M, Majewski J, Albrecht S, McCluggage WG. No small surprise – small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. J Pathol. 2014;233:209–214. - PubMed
    1. Karanian-Philippe M, Velasco V, Longy M, Floquet A, Arnould L, Coindre JM, Le Naoures-Mear C, Averous G, Guyon F, MacGrogan G, Croce S. SMARCA4 (BRG1) loss of expression is a useful marker for the diagnosis of ovarian small cell carcinoma of the hypercalcemic type (ovarian rhabdoid tumor): a comprehensive analysis of 116 rare gynecologic tumors, 9 soft tissue tumors, and 9 melanomas. Am J Surg Pathol. 2015;39:1197–1205. - PubMed

Publication types

LinkOut - more resources