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Case Reports
. 2016 Jun 27;9(2):331-7.
doi: 10.1159/000447258. eCollection 2016 May-Aug.

Advanced Mucinous Adenocarcinoma Arising from a Mature Cystic Teratoma: A Case Report and Literature Review

Aki Miyasaka  1 , Tadaaki Nishikawa  1 , Eito Kozawa  2 , Masanori Yasuda  3 , Keiichi Fujiwara  1 , Kosei Hasegawa  1
Affiliations
Case Reports

Advanced Mucinous Adenocarcinoma Arising from a Mature Cystic Teratoma: A Case Report and Literature Review

Aki Miyasaka et al. Case Rep Oncol. .

Abstract

Purpose: To describe the postoperative progressive course of advanced-stage adenocarcinoma arising from a mature cystic teratoma (MCT) and review the literature regarding this disease.

Methods: A 59-year-old woman visited our hospital with an abdominal mass. Laparotomy showed enlargement of the left ovary and dissemination throughout the abdominal and pelvic cavities. The diagnosis was FIGO stage IIIB adenocarcinoma arising from a MCT. We report this case in detail with a review of the literature.

Results: A literature search yielded 9 cases of stage III adenocarcinoma with malignant transformation. Six of these 9 patients died within 12 months after diagnosis. Of the 8 patients who underwent postoperative chemotherapy, 3 survived for over 39 months. The review indicates that prognosis of adenocarcinoma is as poor as that for squamous cell carcinoma arising from a MCT.

Conclusions: In general, as with this case, prognosis of advanced adenocarcinoma associated with a MCT is poor. However, we should be aware that not all patients are resistant to chemotherapy.

Keywords: Malignant transformation; Mature cystic teratoma; Mucinous adenocarcinoma.

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Figures

Fig. 1
Fig. 1
a A sagittal T2-weighted image showing a large mass with fluid-fluid level in the pelvis. b An axial T2-weighted image showing a large mass with multiple cystic components (arrows). c An axial in-phase T1-weighted image showing a large lobulated mass with some signal intensity. d An axial opposed-phase T1-weighted image showing partial signal loss, as compared to the in-phase T1-weighted image in the central nodule (arrow). This finding indicates that the lesion contains fat and water in the same voxel.
Fig. 2
Fig. 2
a Atypical mucin-containing epithelial cells arranged in a tubular conformation invading the stroma. H&E staining. ×100. b Mature squamous epithelial cells and skin appendages in the background. H&E staining. ×40.
Fig. 3
Fig. 3
Kaplan-Meier survival curve of stage I and III adenocarcinomas. The overall survival rates for stage I and III were about 75 and 30%, respectively. The median survival of stage III was less than 12 months.
See this image and copyright information in PMC

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