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. 2016 Jul 12:8:165.
doi: 10.3389/fnagi.2016.00165. eCollection 2016.

Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease

Ke Sheng  1 , Weidong Fang  2 , Yingcheng Zhu  3 , Guangying Shuai  3 , Dezhi Zou  3 , Meilan Su  3 , Yu Han  3 , Oumei Cheng  3
Affiliations

Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease

Ke Sheng et al. Front Aging Neurosci. .

Abstract

HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset.

Objective: Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective of current paper is to investigate whether characteristics of spontaneous brain activity in the resting state are associated with the age of disease onset.

Methods: We assessed the correlation between neural activity and age-at-onset in a sample of 39 PD patients (18 EOPD and 21 LOPD) and 37 age-matched normal control subjects. Regional homogeneity (ReHo) approaches were employed using ANOVA with two factors: PD and age.

Results: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus. Compared with age-matched control subjects, EOPD exhibited lower ReHo values in the right putamen and higher ReHo values in the left inferior temporal gyrus; However, LOPD showed lower ReHo values in the right putamen and left insula. The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.

Conclusions: Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

Keywords: early-onset Parkinson's disease; late-onset Parkinson's disease; putamen; regional homogeneity; resting-state functional MRI.

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Figures

Figure 1
Figure 1
Statistical maps showing the ReHo differences among patients with EOPD or LOPD and normal controls (P < 0.01, FWE corrected). (A) Compared with LOPD, EOPD showed significantly deceased ReHo values in the right putamen and increased ReHo values in the left superior frontal gyrus. (B) Compared with younger normal controls, EOPD showed significantly deceased ReHo values in the right putamen and increased in the left inferior temporal gyrus. (C) Compared with older normal controls, LOPD exhibited decreased ReHo values in the right putamen and left insula. Red and blue denote higher and lower ReHo values, respectively, and the color bars indicate the T-value from post-hoc analyses between each pair of groups.
Figure 2
Figure 2
Correlation between the mean fitted ReHo index and the UPDRS score in both EOPD and LOPD patients (P < 0.01, uncorrected). A negative correlation was discovered between the ReHo values of the right putamen (x, y, z = 29, 14, 0) and the total UPDRS scores in LOPD patients (r = –0.67, p < 0.01).
See this image and copyright information in PMC

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