Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun;21(2):81-5.
doi: 10.6065/apem.2016.21.2.81. Epub 2016 Jun 30.

The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years

Eun Byul Kwon  1 , Hae Sang Lee  2 , Young Seok Shim  3 , Hwal Rim Jeong  4 , Jin Soon Hwang  2
Affiliations

The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years

Eun Byul Kwon et al. Ann Pediatr Endocrinol Metab. 2016 Jun.

Abstract

Purpose: We studied the changes in subtypes of diabetes mellitus (DM) in children and evaluated the characteristics of each group over the past 20 years. In addition, we also examined the correlation between the glycated hemoglobin (HbA1c) values at the time of diagnosis and lipid profiles.

Methods: The patients were divided into 2 groups: there were a total of 190 patients under 20 years of age firstly diagnosed with DM in Ajou University Hospital. The patients in groups I and II were diagnosed from September 1995 to December 2004 and from January 2005 to April 2014, respectively.

Results: The characteristics were compared between the 2 groups of patients. The result showed an increase in percentage of type 2 diabetes and maturity onset diabetes of the young (MODY) patients between the 2 groups. HbA1c and total cholesterol level had statistical significances to explain increasing the low-density lipoprotein cholesterol level among age, HbA1c, total cholesterol level, and z-scores of weight and body mass index (BMI) in type 2 diabetes. R-square was 0.074. However, z-score of BMI and total cholesterol level, not HbA1c, had statistical significances in type 1 diabetic patients. R-square was 0.323.

Conclusion: The increase in the proportions of both type 2 diabetes and MODY in the last 10 years needed to be reminded when diagnosing the subtypes of DM, and the dyslipidemia should be attended more as a common problem of pediatric diabetic patients.

Keywords: Adolescent; Child; Type 2 diabetes mellitus.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Change of diabetes mellitus types with 2 different periods. Group I (diagnosed from 1995 to 2004); group II (diagnosed from 2005 to 2014); MODY, maturity onset diabetes of the young.
See this image and copyright information in PMC

References

    1. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, et al. Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006;368:1681–1688. - PubMed
    1. Ma RC, Chan JC. Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci. 2013;1281:64–91. - PMC - PubMed
    1. Park J, Oh J, Yu J. Autoantibody positivity and clinical characteristics of diabetes mellitus in childhood. J Korean Soc Pediatr Endocrinol. 2011;16:119–127.
    1. Yang S, Hwang JS, Park HK, Lee HS, Kim HS, Kim EY, et al. Serum lipid concentrations, prevalence of dyslipidemia, and percentage eligible for pharmacological treatment of Korean children and adolescents; data from the Korea National Health and Nutrition Examination Survey IV (2007-2009) PLoS One. 2012;7:e49253. - PMC - PubMed
    1. Lim S, Jang HC, Park KS, Cho SI, Lee MG, Joung H, et al. Changes in metabolic syndrome in American and Korean youth, 1997-2008. Pediatrics. 2013;131:e214–e222. - PubMed

LinkOut - more resources