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Review
. 2016 Sep 6;7(36):58659-58670.
doi: 10.18632/oncotarget.10808.

An updated meta-analysis of 37 case-control studies on the association between NFKB1 -94ins/del ATTG promoter polymorphism and cancer susceptibility

Yi-Qiao Luo  1 , Duan Wang  2 , Teng Gong  3 , Jiang Zhu  4
Affiliations
Review

An updated meta-analysis of 37 case-control studies on the association between NFKB1 -94ins/del ATTG promoter polymorphism and cancer susceptibility

Yi-Qiao Luo et al. Oncotarget. .

Abstract

As a cell survival signal, nuclear factor-kappa B (NFKB) is associated with the pathogenesis of numerous malignancies. According to several studies, NFKB1 -94ins/del ATTG promoter polymorphism is associated with the risk of different malignancies, but the results were not consistent. Therefore, we performed an updated meta-analysis based on 37 case-control studies from 33 articles (16,271 cases and 22,781 controls) to clarify the relationship. The odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association. We found that the NFKB1 -94ins/del ATTG promoter polymorphism was significantly associated with increased susceptibility to cancer in the recessive (II vs. ID+DD, OR = 1.140, 95% CI = 1.029-1.263, p =0.012), homozygote (II vs. DD, OR = 1.259, 95% CI = 1.068-1.485, p =0.006), and allele (I vs. D, OR = 1.109, 95% CI = 1.025-1.199, p =0.010) genetic models. The subgroup analysis for ethnicity found that the NFKB1 -94ins/del ATTG promoter polymorphism was significantly associated with an increased susceptibility to cancer in Asians and with a decreased susceptibility in Caucasians. The stratified analyses revealed significant associations between the polymorphism and increased susceptibility to ovarian cancer, oral squamous cell carcinoma, and nasopharyngeal carcinoma.

Keywords: NFKB1; cancer; meta-analysis; polymorphism.

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Conflict of interest statement

CONFLICT OF INTERESTS Authors declare no financial disclosure or conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of the process for study identification and selection
Figure 2
Figure 2. Forest plots of ORs with 95% CI for the NFKB1 −94ins/del ATTG promoter polymorphism and risk of cancer in the overall population (II vs. ID + DD)
Figure 3
Figure 3. Forest plots of ORs with 95% CI for the NFKB1 −94ins/del ATTG promoter polymorphism and risk of cancer in ethnicity (I vs. D)
Figure 4
Figure 4. Begg's funnel plot of the association between the NFKB1 −94ins/del ATTG promoter polymorphism and risk of cancer (II + ID vs. DD)
See this image and copyright information in PMC

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