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Review
. 2016 Jun;24(6):469-73.
doi: 10.3760/cma.j.issn.1007-3418.2016.06.017.

[Research advances in the role of interleukin-21 in chronic hepatitis B virus infection]

[Article in Chinese]
R Ding  1 , S W Ma  2
Affiliations
Review

[Research advances in the role of interleukin-21 in chronic hepatitis B virus infection]

[Article in Chinese]
R Ding et al. Zhonghua Gan Zang Bing Za Zhi. 2016 Jun.

Abstract

Interleukin-21 (IL-21) is a cytokine mainly secreted by activated CD4+ T cells and natural killer T cells and has multiple effects. It is involved in innate and adaptive immune responses. Recent studies have shown that IL-21 can promote functional activation of various immune cells in the process of hepatitis B virus (HBV) infection, and the gene polymorphisms of IL-21 is associated with the susceptibility to HBV. In addition, the expression of IL-21 is closely associated with HV genotype, HBV clearance, HBeAg seroconversion, HBV-related liver cirrhosis, liver failure, liver cancer, and autoimmune disease. This article reviews the research advances in clinical trials with reference to the aspects above.

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