Synthetic Approaches to Trifluoromethoxy-Substituted Compounds

Abstract

Because of the unique properties of the trifluoromethoxy group, molecules bearing this moiety will find applications in various fields, particularly in the life sciences. However, despite the great interest in this functional group, only a small number of trifluoromethoxylated molecules are currently synthetically accessible. Over the last few years, several innovative and promising strategies for the synthesis of trifluoromethoxylated compounds have been described. This Minireview discusses these existing methods with a particular focus on more recent advances.

Keywords: fluorine; hypervalent iodine compounds; synthetic methods; trifluoromethoxide; trifluoromethoxylation.