Chronic Myelogenous Leukemia Associated with Extranodal B-Cell Lymphoma

Abstract

A 75-year-old man is reported with a 10 year-history of villous adenoma of the colon and carcinoma in situ treated by hemicolectomy. Seven years later, he developed chronic myelogenous leukemia (CML). After a 3-month course of busulfan he was kept off chemotherapy for a one year period. Two years after the diagnosis of CML, an extranodal B-cell lymphoma developed in the left ankle region. A clonal pericentric inversion of chromosome 20 was shown in the lymphoma cells, but without Philadelphia (Ph') chromosome. The possible relation between the two malignant disorders is discussed in the light of current knowledge on the clonal origin of CML.

Keywords: Chronic myelogenous leukemia; Philadephia chromosome; lymphoma; multiple malignancies.