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Review
. 2016 Jul 21;22(27):6135-44.
doi: 10.3748/wjg.v22.i27.6135.

Role of NK, NKT cells and macrophages in liver transplantation

René Fahrner  1 , Felix Dondorf  1 , Michael Ardelt  1 , Utz Settmacher  1 , Falk Rauchfuss  1
Affiliations
Review

Role of NK, NKT cells and macrophages in liver transplantation

René Fahrner et al. World J Gastroenterol. .

Abstract

Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer (NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review.

Keywords: Graft rejection; Ischemia-reperfusion injury; Kupffer cells; Liver transplantation; Natural killer cells.

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Figures

Figure 1
Figure 1
Simplified overview of the role of Kupffer cells, natural killer and natural killer T cells, including the humoral and cellular factors, involved in hepatocyte dysfunction and injury during hepatic ischemia-reperfusion injury. DAMPs: Damage associated molecular pattern; PAMPs: Pathogen-associated molecular pattern; ROS: Reactive oxygen species; TNF: Tumor necrosis factor; IFN: Interferon; iNOS: Inducible nitric oxide synthase; SEC: Sinusoidal endothelial cells.
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