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Comment
. 2016 Sep 15;35(18):1960-2.
doi: 10.15252/embj.201695185. Epub 2016 Jul 28.

Mitochondrial DNA mutations in iPS cells: mtDNA integrity as standard iPSC selection criteria?

Riikka H Hämäläinen  1
Affiliations
Comment

Mitochondrial DNA mutations in iPS cells: mtDNA integrity as standard iPSC selection criteria?

Riikka H Hämäläinen. EMBO J. .

Abstract

Somatic cells harbor random heteroplasmic mitochondrial DNA mutations, which are considered to contribute to aging. In this issue of The EMBO Journal, Perales‐Clemente et al (2016) show that mtDNA mutations, present at low levels in the starting fibroblasts, become enriched in iPS cells and lead to functional defects in iPS‐derived cells. In another recent study, Kang et al (2016) demonstrated that accumulation of mtDNA mutations of somatic origin in iPSCs is age related.

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Figures

Figure 1
Figure 1. iPS cells harbor mitochondrial DNA mutations
Low levels of heteroplasmic mtDNA mutations are present in somatic cells. Perales‐Clemente and colleagues show that these may become enriched in clonal iPS lines and lead to respiratory defects in differentiated cells derived from the iPS cells.
See this image and copyright information in PMC

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References

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