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Review
. 2016 Sep;9(5):541-8.
doi: 10.1111/1751-7915.12388. Epub 2016 Jul 29.

Antibiotic drug discovery

Wolfgang Wohlleben  1   2 , Yvonne Mast  1   2 , Evi Stegmann  1   2 , Nadine Ziemert  1   2
Affiliations
Review

Antibiotic drug discovery

Wolfgang Wohlleben et al. Microb Biotechnol. 2016 Sep.

Abstract

Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.

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Figures

Figure 1
Figure 1
Approaches in natural product discovery aiming to identify novel antibiotics.
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