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. 2016 Nov-Dec;210(1-2):10-12.
doi: 10.1016/j.molbiopara.2016.07.006. Epub 2016 Jul 26.

Comparison of a new visual isothermal nucleic acid amplification test with PCR and skin snip analysis for diagnosis of onchocerciasis in humans

Andy Alhassan  1 , Mike Y Osei-Atweneboana  2 , Kwadwo F Kyeremeh  3 , Catherine B Poole  1 , Zhiru Li  1 , Edward Tettevi  2 , Nathan A Tanner  1 , Clotilde K S Carlow  4
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Free article

Comparison of a new visual isothermal nucleic acid amplification test with PCR and skin snip analysis for diagnosis of onchocerciasis in humans

Andy Alhassan et al. Mol Biochem Parasitol. 2016 Nov-Dec.
Free article

Abstract

Accurate, simple and affordable diagnostics are needed to detect Onchocerca volvulus infection in humans. A newly developed colorimetric loop-mediated isothermal amplification (LAMP) assay was compared to PCR and skin snip analysis for diagnosis of onchocerciasis. The robustness and simplicity of the assay indicates that it may be a useful field tool for surveillance in endemic countries.

Keywords: Colorimetric LAMP; Diagnosis; O-150 repeat; Onchocerciasis; Skin snips.

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