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Comment
. 2017 Apr;66(4):756-758.
doi: 10.1136/gutjnl-2016-312398. Epub 2016 Jul 29.

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency

Soesma A Jankipersadsing  1   2 , Fatemeh Hadizadeh  3   4 , Marc Jan Bonder  2 , Ettje F Tigchelaar  2   5 , Patrick Deelen  2   6 , Jingyuan Fu  1   2 , Anna Andreasson  7   8 , Lars Agreus  7 , Susanna Walter  9 , Cisca Wijmenga  2 , Pirro Hysi  10 , Mauro D'Amato  3   11 , Alexandra Zhernakova  2   6
Affiliations
Comment

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency

Soesma A Jankipersadsing et al. Gut. 2017 Apr.
No abstract available

Keywords: CYTOCHROME P450; GENETICS; INTESTINAL MOTILITY; META-ANALYSIS.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Manhattan plot of the results from the meta-analysis of LifeLines-Deep (LLD) and PopCol (PC) genome-wide association studies. Single-nucleotide polymorphisms (SNPs) which are sorted according to their genomic positions are displayed on the X-axis, and the negative logarithm of the association p value for each SNP after meta-analysis is displayed on the Y-axis; each dot represents a SNP with a certain p value. The top-10 loci are indicated by numbers. Per locus, the statistics of the lead SNPs are shown, including the positions in the genome, the nearest genes and the genes in a 250 kb window around the lead SNPs. The effect of the assessed allele at each locus is indicated by beta; negative betas mean negative effect on the average number of bowel movements per day (BM/d) (decreased number of stool passes) and positive betas mean positive effect on the average number of BM/d (increased number of stool passes). Beta, direction of association; BP, base pair position; Chr, chromosome; SE, SE of the beta.
See this image and copyright information in PMC

Comment in

  • TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M.
    Henström M, Hadizadeh F, Beyder A, Bonfiglio F, Zheng T, Assadi G, Rafter J, Bujanda L, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Talley NJ, Simren M, Walter S, Wouters M, Farrugia G, D'Amato M. Henström M, et al. Gut. 2017 Sep;66(9):1725-1727. doi: 10.1136/gutjnl-2016-313346. Epub 2016 Dec 14. Gut. 2017. PMID: 27974553 Free PMC article. No abstract available.

Comment on

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