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. 2016 Nov;138(5):1467-1471.e9.
doi: 10.1016/j.jaci.2016.04.044. Epub 2016 Jun 15.

Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children

David B Kantor  1 , Nicole Stenquist  2 , Molly C McDonald  3 , Blake J Schultz  2 , Marissa Hauptman  4 , Craig D Smallwood  2 , Kyle A Nelson  5 , Matthew S Perzanowski  6 , Elizabeth C Matsui  7 , Wanda Phipatanakul  8 , Joel N Hirschhorn  9
Affiliations

Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children

David B Kantor et al. J Allergy Clin Immunol. 2016 Nov.
No abstract available

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Conflict of interest statement

of potential conflict of interest: The rest of the authors declare that they have no relevant conflicts of interest.

Figures

Fig 1
Fig 1
Rhinovirus infection interacts with mouse-specific and dust mite–specific IgE levels in relation to acute asthma exacerbation severity. A, Rhinovirus-positive subjects (hRV+, n = 95) demonstrate higher acute severity than do virus-negative subjects (virus –, n = 60). The linear regression coefficient, 95% CI, and P value are shown (multivariate analysis adjusted for age, sex, race, annual income, lung function, baseline asthma severity, symptom duration, medication adherence, total number of ImmunoCAP positives, and season). Rhinovirus infection interacts with both baseline mouse-specific (B) and dust mite–specific IgE (C) levels. For panels (B) and (C), the linear regression coefficients, 95% CIs, and P values for the interaction between rhinovirus status and the respective allergen-specific IgE levels are shown. coef, Coefficient.
Fig 2
Fig 2
Rhinovirus infection is associated with an acute rise in IgE levels. Rhinovirus (hRV+, n = 95) is associated with an acute increase in mouse-specific (A), dust mite–specific (B), and total IgE (C) levels compared with virus-negative subjects (virus–, n = 60). IgE levels are expressed as the fold-change of exacerbation levels over baseline levels. For panels (A), (B), and (C), linear regression coefficients, 95% CIs, and P values are shown (multivariate analysis adjusted for age, sex, race, season, and time between measurement of exacerbation and baseline IgE levels). Rhinovirus interacts with the fold-change in both mouse-specific (D), and dust mite–specific IgE (E) levels in terms of acute asthma severity, but not with total IgE level (F). For panels (D), (E), and (F), the linear regression coefficients, 95% CIs, and P values for the interaction between rhinovirus status and fold-change in IgE levels are shown (multivariate analyses adjusted for age, sex, race, annual income, lung function, baseline asthma severity, symptom duration, medication adherence, total number of ImmunoCAP positives, and season). coef, Coefficient.
See this image and copyright information in PMC

Comment in

  • IgE and antiviral immune response in asthma.
    Tam JS, Grayson MH. Tam JS, et al. J Allergy Clin Immunol. 2017 May;139(5):1717. doi: 10.1016/j.jaci.2016.11.055. Epub 2017 Mar 6. J Allergy Clin Immunol. 2017. PMID: 28274583 No abstract available.
  • Reply.
    Kantor DB, Phipatanakul W, Hirschhorn JN. Kantor DB, et al. J Allergy Clin Immunol. 2017 May;139(5):1717-1718. doi: 10.1016/j.jaci.2016.11.054. Epub 2017 Mar 6. J Allergy Clin Immunol. 2017. PMID: 28274584 Free PMC article. No abstract available.

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