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Review
. 2017 Mar 15:304:29-34.
doi: 10.1016/j.jneuroim.2016.07.007. Epub 2016 Jul 17.

SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

Vamshi K C Nimmagadda  1 , Tapas K Makar  2 , Krish Chandrasekaran  3 , Avinash Rao Sagi  3 , Jayanta Ray  3 , James W Russell  1 , Christopher T Bever Jr  4
Affiliations
Review

SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

Vamshi K C Nimmagadda et al. J Neuroimmunol. .

Abstract

Neurodegeneration is an important determinant of disability in multiple sclerosis (MS) but while currently approved treatments reduce inflammation, they have not been shown to reduce neurodegeneration. SIRT1, a NAD dependent protein deacetylase, has been implicated in the pathogenesis of neurodegeneration in neurological diseases including MS. We have studied the role of SIRT1 in experimental autoimmune encephalomyelitis (EAE) and found evidence for a neuroprotective role. In this review we summarize the most recent findings from the use of SIRT1 activators and SIRT1 overexpression in transgenic mice. These data support provide a rational for the use of SIRT1 activators in MS.

Keywords: EAE; Multiple sclerosis; NAD; Neurodegeneration; SIRT1.

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References

    1. Aguilar-Arnal L, Katada S, Orozco-Solis R, Sassone-Corsi P. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 2015;22(4):312–318. - PMC - PubMed
    1. Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC. NMNATs, evolutionarily conserved neuronal maintenance factors. Trends Neurosci. 2013;36(11):632–640. - PMC - PubMed
    1. Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science. 2004;305(5686):1010–1013. - PubMed
    1. Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008;134(2):317–328. - PubMed
    1. Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A. The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep. 2013;3(5):1422–1429. - PMC - PubMed

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