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Review
. 2016 Jul;36(4):305-18.
doi: 10.1016/j.semnephrol.2016.05.007.

Consequences of CKD on Functioning

Piyawan Kittiskulnam  1 , Anoop Sheshadri  2 , Kirsten L Johansen  3
Affiliations
Review

Consequences of CKD on Functioning

Piyawan Kittiskulnam et al. Semin Nephrol. 2016 Jul.

Abstract

Chronic kidney disease (CKD) is highly prevalent in the United States and throughout the world,(1) with approximately 13% of adults affected.(2) In addition, according to recent estimates, almost half of patients with CKD stages 3 to 5 are 70 years of age and older.(2) In the United States, the number of prevalent end-stage renal disease cases continues to increase in patients older than age 65. In light of the demographic characteristics of patients with CKD and ESRD, there has been considerable focus on associations between CKD and cardiovascular outcomes.(3) Until recently, less attention had been paid to other consequences of CKD in general and among older individuals with CKD in particular, but there is now solid evidence linking CKD with impairments of physical function, cognitive function, and emotional function and quality of life. This review summarizes available literature on these topics, focusing specifically on physical functioning and frailty, cognitive function, emotional health, including depression and anxiety, and health-related quality of life.

Keywords: Chronic kidney disease; cognitive function; depression; frailty; health-related quality of life; physical function.

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Figures

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Potential causes of cognitive dysfunction in CKD.
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References

    1. USRDS 2015 Annual Data Report. Atlas of Chronic Disease and End Stage Renal Disease in the United States. [November 19, 2015] Available from: http://www.usrds.org/2015/view/v2_01.aspx.
    1. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. Jama. 2007;298:2038–47. - PubMed
    1. Deo R, Fyr CL, Fried LF, Newman AB, Harris TB, Angleman S, et al. Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study. Am Heart J. 2008;155:62–8. - PubMed
    1. Konstantinidou E, Koukouvou G, Kouidi E, Deligiannis A, Tourkantonis A. Exercise training in patients with end-stage renal disease on hemodialysis: comparison of three rehabilitation programs. J Rehabil Med. 2002;34:40–5. - PubMed
    1. Storer TW, Casaburi R, Sawelson S, Kopple JD. Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients. Nephrol Dial Transplant. 2005;20:1429–37. - PubMed

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