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Randomized Controlled Trial
. 2016 Sep 1;21(5):e621-5.
doi: 10.4317/medoral.21161.

Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study

V-S Todorovic  1 , M Vasovic, M Andric, L Todorovic, V Kokovic
Affiliations
Randomized Controlled Trial

Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study

V-S Todorovic et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery.

Material and methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS).

Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p<0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p<0.05).

Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.

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Conflict of interest statement

The authors have declared that no conflict of interest exist.

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