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. 2016 Sep 1;21(5):e626-30.
doi: 10.4317/medoral.21170.

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

S-A Danesh-Sani  1 , A Sarafraz, M Chamani, H Derakhshandeh
Affiliations

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

S-A Danesh-Sani et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Inadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors.

Material and methods: Clinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor.

Results: There were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy.

Conclusions: Paranasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies.

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Conflict of interest statement

The authors have declared that no conflict of interest exist.

Figures

Figure 1
Figure 1
Histological types of tumors.
See this image and copyright information in PMC

References

    1. Khademi B, Moradi A, Hoseini S, Mohammadianpanah M. Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis. Oral Maxillofac Surg. 2009;13:191–9. - PubMed
    1. Grau C, Jakobsen MH, Harbo G, Svane-Knudsen V, Wedervang K, Larsen SK. Sino-nasal cancer in Denmark 1982-1991-a nationwide survey. Acta Oncol. 2001;40:19–23. - PubMed
    1. Svane-Knudsen V, Jorgensen KE, Hansen O, Lindgren A, Marker P. Cancer of the nasal cavity and paranasal sinuses: a series of 115 patients. Rhinology. 1998;36:12–4. - PubMed
    1. Dirix P, Nuyts S, Geussens Y, Jorissen M, Vander Poorten V, Fossion E. Malignancies of the nasal cavity and paranasal sinuses: long-term outcome with conventional or three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69:1042–50. - PubMed
    1. Harbo G, Grau C, Bundgaard T, Overgaard M, Elbrond O, Sogaard H. Cancer of the nasal cavity and paranasal sinuses. A clinico-pathological study of 277 patients. Acta Oncol. 1997;36:45–50. - PubMed