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. 2016 Aug:806:40-6.
doi: 10.1016/j.mrgentox.2016.07.005. Epub 2016 Jul 11.

Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro

Emiliano Basso  1 , Giulia Regazzo  1 , Mario Fiore  2 , Valentina Palma  3 , Gianandrea Traversi  1 , Antonella Testa  3 , Francesca Degrassi  2 , Renata Cozzi  4
Affiliations

Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro

Emiliano Basso et al. Mutat Res Genet Toxicol Environ Mutagen. 2016 Aug.

Abstract

Resveratrol (3,4',5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity.

Keywords: Ionizing radiations resveratrol dicentrics ƴH2AX DNA damage repair HDAC activity.

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