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. 2016 Jul 29:10:24.
doi: 10.1186/s13030-016-0075-3. eCollection 2016.

Inhibition of emotional needs and emotional wellbeing predict disease progression of chronic hepatitis C patients: an 8-year prospective study

Ryoko Sawamoto  1 , Jun Nagano  2 , Eiji Kajiwara  3 , Junko Sonoda  1 , Tetsuya Hiramoto  1 , Nobuyuki Sudo  1
Affiliations

Inhibition of emotional needs and emotional wellbeing predict disease progression of chronic hepatitis C patients: an 8-year prospective study

Ryoko Sawamoto et al. Biopsychosoc Med. .

Abstract

Background: The role of psycosocial factors in the disease progression of chronic hepatitis C (CHC) patients remains unclear. The aim of the present study was to prospectively evaluate the prognostic value of behavioral patterns and the quality of life (QOL) of patients with CHC.

Methods: Two hundred and forty Japanese CHC patients (mean age 62.4 years) were assessed for behavioral patterns (Stress Inventory), QOL (Functional Assessment of Chronic Illness Therapy-Spiritual), and known prognostic factors at baseline then followed for a maximum of 8 years for disease progression, defined as either the first diagnosis of hepatocellular carcinoma (HCC) or hepatitis-related death.

Results: Forty-nine events occurred during the study period (46 newly diagnosed HCC cases, three hepatitis-related deaths). In a Cox proportional hazard model including known prognostic factors and treatment-related factors as time-dependent variables, behavioral patterns associated with inhibition of emotional needs (hazard ratio (HR): 1.35; 95 % confidence interval (CI): 1.02-1.77; p = 0.036) and QOL, representing emotional wellbeing (HR 0.60; 95 % CI 0.37-0.98; p = 0.041), were each associated with the risk of disease progression.

Conclusion: Psychosocial factors such as behavioral patterns relevant to the inhibition of emotional needs and emotional wellbeing independently affect the clinical course of patients with CHC.

Keywords: Chronic hepatitis; Emotion; Hepatocellular carcinoma; Prognosis; Psychosocial stress; Quality of life.

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References

    1. Hepatitis C Fact sheet. WHO media center. [WWW Document] URL http://www.who.int/hiv/topics/hepatitis/en/. Accessed 24 July 2016.
    1. Bruno S, Crosignani A, Maisonneuve P, Rossi S, Silini E, Mondelli MU. Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study. Hepatology. 2007;46:1350–1356. doi: 10.1002/hep.21826. - DOI - PubMed
    1. Fattovich G, Llovet JM. Risk factors for hepatocellular carcinoma in HCV-cirrhosis: what we know and what is missing. J Hepatol. 2006;44:1013–6. doi: 10.1016/j.jhep.2006.04.001. - DOI - PubMed
    1. Chida Y, Sudo N, Sonoda J, Sogawa H, Kubo C. Electric foot-shock stress-induced exacerbation of α-galactosylceramide-triggered apoptosis in the house liver. Hepatology. 2004;39:1131–40. doi: 10.1002/hep.20158. - DOI - PubMed
    1. Chida Y, Sudo N, Takaki A, Kubo C. The hepatic sympathetic nerve plays acritical role in preventing Fas induced liver injury in mice. Gut. 2005;54(7):994–1002. doi: 10.1136/gut.2004.058818. - DOI - PMC - PubMed

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