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. 2016 Aug;9(4):572-5.
doi: 10.1093/ckj/sfw025. Epub 2016 May 4.

Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

Andrew P Groves  1 , Patrick Reich  2 , Binayak Sigdel  3 , T Keefe Davis  4
Affiliations

Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

Andrew P Groves et al. Clin Kidney J. 2016 Aug.

Abstract

Pneumococcal-associated hemolytic uremic syndrome (pHUS) is a rare but severe complication of invasive Streptococcus pneumoniae infection. We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar(®) Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication.

Keywords: Acthar; hemolytic; nephrotic; streptococcus; uremic.

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Figures

Fig. 1.
Fig. 1.
A mechanism of endothelial cell injury in Streptococcal Pneumoniae associated hemolytic uremic syndrome.
See this image and copyright information in PMC

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