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Review
. 2016:2016:4189358.
doi: 10.1155/2016/4189358. Epub 2016 Jul 10.

Endoscopic Ultrasound-Guided Radiofrequency Ablation of the Pancreatic Tumors: A Promising Tool in Management of Pancreatic Tumors

Kinesh Changela  1 , Rashmee Patil  2 , Sushil Duddempudi  1 , Vinaya Gaduputi  3
Affiliations
Review

Endoscopic Ultrasound-Guided Radiofrequency Ablation of the Pancreatic Tumors: A Promising Tool in Management of Pancreatic Tumors

Kinesh Changela et al. Can J Gastroenterol Hepatol. 2016.

Abstract

Objective. Radiofrequency ablation is a well-established antitumor treatment and is recognized as one of the least invasive therapeutic modalities for pancreatic neoplasm. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) delivery can be used to treat both pancreatic cancer and asymptomatic premalignant pancreatic neoplasms and may serve as a less invasive alternative to surgical resection. This is an appealing option that may result in less morbidity and mortality. The aim of this review was to summarize and evaluate the clinical and technical effectiveness of EUS-guided RFA of pancreatic neoplasms. Methods. A through literature review was performed to identify the studies describing this novel technique. In this review article, we have summarized human case series. The indications, techniques, limitations, and complications reported are discussed. Results. A total of six studies were included. Overall, a 100% technical success rate was reported in human studies. Complications related to endoscopic ultrasound-guided radiofrequency ablation delivery have been described; however, few cases have presented life-threatening outcomes. Conclusion. We believe that this novel technique can be a safe and effective alternative approach in the management of selected patients.

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Figures

Figure 1
Figure 1
Habib™ EUS-RFA probe (reproduced from manufacturer's website with appropriate permission [4]).
Figure 2
Figure 2
Endoscopic ultrasound view showing EUS-RFA probe inserted into the porcine pancreas (the porcine pancreatic tissue was ablated with RFA after placing EUS-guided 19-gauge Wilson Cook needle into the pancreas via transduodenal approach) (reproduced from an open access article under terms of the Creative Commons Attribution License [4]).
Figure 3
Figure 3
Pathological specimen of porcine pancreas (on the 6th day after procedure, the pigs were euthanized. The pancreas of the pigs was immediately excised surgically for gross examination of damage and tissue response) (reproduced from an open access article under terms of the Creative Commons Attribution License [4]).
See this image and copyright information in PMC

References

    1. Brugge W. R. EUS-guided tumor ablation with heat, cold, microwave, or radiofrequency: will there be a winner? Gastrointestinal Endoscopy. 2009;69(2):S212–S216. doi: 10.1016/j.gie.2008.12.031. - DOI - PubMed
    1. Varadarajulu S., Jhala N. C., Drelichman E. R. EUS-guided radiofrequency ablation with a prototype electrode array system in an animal model (with video) Gastrointestinal Endoscopy. 2009;70(2):372–376. doi: 10.1016/j.gie.2009.03.008. - DOI - PubMed
    1. Kim J. Endoscopic ultrasound-guided treatment of pancreatic cystic and solid masses. Clinical Endoscopy. 2015;48(4):308–311. doi: 10.5946/ce.2015.48.4.308. - DOI - PMC - PubMed
    1. Gaidhane M., Smith I., Ellen K., et al. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) of the pancreas in a porcine model. Gastroenterology Research and Practice. 2012;2012:6. doi: 10.1155/2012/431451.431451 - DOI - PMC - PubMed
    1. Yoon W. J., Brugge W. R. Endoscopic ultrasonography-guided tumor ablation. Gastrointestinal Endoscopy Clinics of North America. 2012;22(2):359–369. doi: 10.1016/j.giec.2012.04.017. - DOI - PubMed

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