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Comment
. 2016 Sep;100(9):e52-3.
doi: 10.1097/TP.0000000000001365.

The Authors' Reply

Robert C Williams  1 , Gerhard Opelz, E Jennifer Weil, Chelsea J McGarvey, Harini A Chakkera
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The Authors' Reply

Robert C Williams et al. Transplantation. 2016 Sep.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A line was fitted to the hazard ratios from a fully adjusted Cox regression for transplants in the UNOS data set for first adult kidney transplants with HLA mismatch as the primary explanatory variable. Blue diamonds are the observed HRs for deceased donors 1987-2013 with the blue fitted line; the intercept is 1.04 (0.98, 1.10), p < 0.0001, while the slope is 0.11 (0.09, 0.12), p < 0.0001. Red squares are observed HRs for all transplants 2009-2013 with the fitted red line; the intercept is 1.08 (0.98, 1.17), p <0.0001 while the slope of the line is 0.08 (0.06, 0.10), p = 0.0003. Adjustment was for recipient age, donor age, donor sex, transplant era, recipient ethnicity, recipient diabetes, cold ischemia time, recipient peak PRA, recipient education, recipient BMI, donor BMI, recipient working for income at transplant, recipient COPD, recipient dialysis type, induction and immunosuppression at discharge.
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References

    1. Mjøen G, Reisaeter AV, Dahle DO. HLA mismatch and allograft survival. Transplantation. 2016 XXX:XXXX-XXXX. - PubMed
    1. Williams RC, Opelz G, McGarvey CJ, Weil EJ, Chakkera HA. The risk of transplant failure with HLA mismatch in first adult kidney allografts from deceased donors. Transplantation. 2016;100:1094–1102. - PMC - PubMed